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Purpose
Refractoriness can occur after repeated platelet (PLT) transfusions because of alloimmunization to HLA class I antigens on transfused PLTs and generation of anti‐HLA antibodies that bind to the foreign PLTs and initiate their destruction. Such refractoriness can be overcome by provision of HLA‐matched PLTs from HLA typed donors. However, since the procedure is both expensive and time‐consuming,...
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