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Background
Dysfunction of mitochondrial energy generation may contribute to neurodegeneration, leading to synaptic loss in Parkinson's disease (PD). The objective of this study was to find cross‐sectional and longitudinal changes in PET markers of synaptic vesicle protein 2A, sigma 1 receptor, and mitochondrial complex 1 in drug‐naive PD patients.
Methods
Twelve early drug‐naive PD patients and...
Background
Recent work has shown loss of phosphodiesterase 10A levels in middle‐stage and advanced treated patients with PD, which was associated with motor symptom severity.
Objectives
To assess phosphodiesterase 10A levels in early PD and compare with loss of dopamine transporter as markers of disease burden.
Methods
Seventy‐eight subjects were included in this study (17 early de novo, 15 early...
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