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Cocaine induces many supranormal changes in neuronal activity in the brain, notably in learning‐ and reward‐related regions, in comparison with nondrug rewards—a difference that is thought to contribute to its relatively high addictive potential. However, when facing a choice between cocaine and a nondrug reward (e.g., water sweetened with saccharin), most rats do not choose cocaine, as one would...
Drug addiction is a harmful preference for drug use over and at the expense of other non‐drug‐related activities. We previously identified in the rat orbitofrontal cortex (OFC) a mechanism that influences individual preferences between cocaine use and an alternative action rewarded by a non‐drug reward (i.e. sweet water). Here, we sought to test the generality of this mechanism to a different addictive...
Based on neuro‐imaging studies in cocaine‐addicted humans, it is hypothesized that increases in neural activity within several regions of the prefrontal cortex contribute to cue‐induced cocaine seeking and cocaine‐induced compulsive drug self‐administration. However, electrophysiological tests of these hypotheses are lacking. In the present study, animals were trained to self‐administer cocaine (0...
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