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The molecular circuits by which antigens activate quiescent T cells remain poorly understood. We combined temporal profiling of the whole proteome and phosphoproteome via multiplexed isobaric labeling proteomics technology, computational pipelines for integrating multi-omics datasets, and functional perturbation to systemically reconstruct regulatory networks underlying T cell activation. T cell receptors...
T-cell-dependent immunity in the central nervous system (CNS) is beneficial for neuroprotection, neurogenesis and even behavior. As a highly specialized site, the CNS is speculated to possess the means to maintain T-cell immune responses through its own resident cells. Therefore, we investigated whether microglia, the most potent antigen-presenting cells residing in the CNS, could sustain T-cell responses...
Glucocorticoids (GC) are essential neuroendocrine regulators of the immune system during stress, and prolonged psychological stress has been shown to be immunosuppressive. However, little is known about how GC influence the role of microglia, the most potent antigen presenting cell (APC) residing in the central nervous system (CNS), in the T cell immune response during stress. Therefore, we investigated...
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