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Chimeric antigen receptor T cell (CAR‐T) therapy has shown remarkable clinical success in eradicating hematologic malignancies. However, hostile microenvironment in solid tumors severely prevents CAR‐T cells migrating, infiltrating, and killing. Herein, a nanoengineered CAR‐T strategy is reported for enhancing solid tumor therapy through bioorthogonal conjugation with a nano‐photosensitizer (indocyanine...
Metal complexes are widely used as anticancer drugs, while the severe side effects of traditional chemotherapy require new therapeutic modalities. Sonodynamic therapy (SDT) provides a significantly noninvasive ultrasound (US) treatment approach by activating sonosensitizers and initiating reactive oxygen species (ROS) to damage malignant tissues. In this work, three metal 4‐methylphenylporphyrin (TTP)...
Phase‐engineered type‐II metal–selenide heterostructures are demonstrated by directly selenizing indium‐tin oxide to form multimetal selenides in a single step. The utilization of a plasma system to assist the selenization facilitates a low‐temperature process, which results in large‐area films with high uniformity. Compared to single‐metal–selenide‐based photodetectors, the multimetal–selenide photodetectors...
Carbonaceous nanotubes (CTs) represent one of the most popular and effective carbon electrode materials for supercapacitors, but the electrochemistry performance of CTs is largely limited by their relatively low specific surface area, insufficient usage of intratube cavity, low content of heteroatom, and poor porosity. An emerging strategy for circumventing these issues is to design novel porous CT‐based...
The formation of PtSe2‐layered films is reported in a large area by the direct plasma‐assisted selenization of Pt films at a low temperature, where temperatures, as low as 100 °C at the applied plasma power of 400 W can be achieved. As the thickness of the Pt film exceeds 5 nm, the PtSe2‐layered film (five monolayers) exhibits a metallic behavior. A clear p‐type semiconducting behavior of the PtSe...
In article number 1704015, Xiaoming Yang and co‐workers engineer a spheres‐in‐tube nanostructure with hierarchical porosity by encapsulating heteroatom‐doping hollow carbon spheres into one carbonaceous nanotube. This nanoarchitecture integrates the merits of large specific surface area, good porosity and high content of heteroatoms, which synergistically facilitates the transportation and exchange...
In article number 1703207, Jianjun Chen, Zongqiang Cui, and co‐workers develop an intranasal nanovaccine which provides protection against homo‐ and heterosubtypic influenza. The 3M 2e‐rHF nanovaccine is constructed by displaying three‐sequential repeats of the influenza conserved antigen M2e on the self‐assembling recombinant human heavy chain ferritin (rHF) cage. Intranasal vaccination with 3M2e‐rHF...
Cross‐protective and non‐invasively administered vaccines are attractive and highly desired for the control of influenza. Self‐assembling nanotechnology provides an opportunity for the development of vaccines with superior performance. In this study, an intranasal nanovaccine is developed targeting the conserved ectodomain of influenza matrix protein 2(M2e). 3‐sequential repeats of M2e (3M2e) is presented...
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