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Cardiac arrest (CA)‐induced cerebral ischemia remains challenging with high mortality and disability. Neural stem cell (NSC) engrafting is an emerging therapeutic strategy with considerable promise that, unfortunately, is severely compromised by limited cell functionality after in vivo transplantation. This groundbreaking report demonstrates that metabolic glycoengineering (MGE) using the “Ac5ManNTProp...
Neural Stem Cells
In article number 2309866, Xiaofeng Jia and co‐workers employ metabolic glycoengineering (MGE) to modify neural stem cells (NSCs) to treat ischemic brain injury after cardiac arrest. The ex vivo pretreatment with thiol‐modified sugar analogs improve neuronal differentiation of NSCs and then, upon transplantation, further enhances the in vivo therapeutic efficacy of stem cell therapy...