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Accumulating evidence has reported that nitric oxide (NO) can be cytotoxic and induce apoptosis. NO can also be genotoxic and cause DNA damage and mutations. It has been shown that NO damages mitochondrial DNA (mtDNA) to a greater extent than nuclear DNA. Sodium Nitroprusside (SNP), a NO donor, could efficiently promote NO formation. The viability of retinal ganglion cells (RGC) and the mtDNA copy...
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