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Bone defect regeneration depends on the population and lifespan of M2 macrophages, which are regulated by dual signals generated by the “physical” spatial configuration of biological tissues and “molecular” chemokines. Herein, inspired by the reprogramming of macrophages, immunoengineered porous microspheres are constructed to accelerate bone repair through the regulation of both “physical” and “molecular”...
Bone Defect Treatment
Inspired by the concept of macrophage reprogramming, Wenguo Cui, Youcheng Yu, and co‐workers construct immuno‐engineering porous microspheres (IL‐4/loaded liposomes (Ls)/poly (l‐lactic acid) (PLLA)) to realize bone repair through the “physical” porous structure and “molecular” IL‐4 chemokines dual signal regulation. The immuno‐reprogramming IL‐4/Ls/PLLA microspheres achieve the...
Micromotors
With a hybrid sonoelectrode, distinctive swarming behaviors of classical micromotors in dispersion and aggregation patterns are universally tailored by modulating the applied acoustic field in a micro‐reservoir, which offers great potentials for next‐generation active detection microsystems. More information can be found in article number 2104516 by Xiaolong Lu and co‐workers.
Enabled by active motion of microrobots, conventional biological detection and chemical analyses limited by passive diffusion can be significantly enhanced with fast testing speed and unique sensitiveness. However, controlled release and precise enrichment of microrobot swarms are still difficult to accomplish and thus prohibit them away from practical applications. Here, an efficient and versatile...
In article number 2003678, Xiaolong Lu, Wenjuan Liu, and co‐workers report dandelion‐like microswarms assembled from tubular micromotors, which are capable of performing ultrafast growth and locomotion. With the ultrasound oscillation of self‐generated bubbles, such microswarms could move at an average speed of up to 50 mm s−1 and exhibit an instant and wireless response to ultrasound stimuli.
Dynamic assembly and cooperation represent future frontiers for next generations of advanced micro/nano robots, but the required local interaction and communication cannot be directly translated from macroscale robots through the minimization because of tremendous technological challenges. Here, an ultrafast growth and locomotion methodology is presented for dandelion‐like microswarms assembled from...
Artificial micro/nanomotors that could perform diverse tasks autonomously at the micro/nanoscale have been emerging as promising tools in many practical applications. Electrochemical synthesis is one of the dominating methods to fabricate these micro/nanodevices with diverse geometries and material components. By changing the conditions of electrochemical deposition, the surface morphology, crystal...
Artificial micro/nanomotors that could perform diverse tasks autonomously at the micro/nano scale hold great promise in environmental remediation applications. In article number 1802771, Wenjuan Liu, Xiaolong Lu, Jinxing Li, Joseph Wang, and co‐workers synthesize highly efficient tubular poly(3,4‐ethylenedioxythiophene)/MnO2 micromotors via potentiostatic deposition to obtain unique ramsdellite structures...
The delivery of tumor‐suppressive noncoding RNAs (ncRNAs) including short ncRNAs (i.e., miRNAs) and long ncRNAs (lncRNAs) is put forward to treat tumors. In this work, novel rodlike supramolecular nanoassemblies (CNC @CB[8] @ PGEA) of degradable poly(aspartic acid) (PAsp) derivatives‐grafted cellulose nanocrystals (CNCs) and hydroxyl‐rich polycations (ethanolamine‐functionalized poly(glycidyl methacrylate),...
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