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Two new parthenolide analogues were obtained by total synthesis and assayed for their in vitro anticancer activities to study their structure–activity relationship. Based on the structure and anticancer activity results, two new SAR can be drawn: (1) replacement of the lactone moiety with lactam moiety greatly decreased the anticancer activity; (2) the C-14 methyl group of parthenolide might be important...
Two [2]catenanes, in which one calix[4]arene subunit is incorporated into the tetracationic ring, have been synthesized, the calix[4]arene moieties influence remarkably the conformation and solubility of the resulting catenanes.
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