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Electrochemical biosensors based on structure‐switching aptamers offer many advantages because they can operate directly in complex samples and offer the potential to integrate with miniaturized electronics. Unfortunately, these biosensors often suffer from cross‐reactivity problems when measuring a target in samples containing other chemically similar molecules, such as precursors or metabolites...
Electrochemical Aptamer Biosensors
In article number 2208534, Fu, Soh, and co‐workers report an electrochemical biosensor to distinguish molecules with a minuscule difference in chemical composition by tuning the charge state of the surface on which the aptamer probes are immobilized. As an exemplar, it is shown that the strategy can distinguish between doxorubicin and many structurally similar analytes,...
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