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Characterize the cellular and molecular events responsible for lipodystrophy in AGPAT2 deficient mice.Adipose tissue and differentiated MEF were assessed using light and electron microscopy, followed by protein (immunoblots) and mRNA analysis (qPCR). Phospholipid profiling was determined by electrospray ionization tandem mass spectrometry (ESI-MS/MS).In contrast to adult Agpat2−/− mice, fetuses and...
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