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Objective
In vitro studies suggest that the type I interferon (IFN) signature seen in most lupus patients results from Fcγ receptor–mediated uptake of nucleic acid–containing immune complexes by plasmacytoid dendritic cells and engagement of endosomal Toll‐like receptors. The aim of this study was to reexamine the pathogenesis of the IFN signature in vivo.
Methods
Lupus was induced in mice by injecting...
ObjectiveTumor necrosis factor α (TNFα) antagonists are effective for treating rheumatoid arthritis and other inflammatory diseases, but their use can be complicated by the development of lupus‐like phenomena. This study was undertaken to investigate the role of TNFα in a murine model of lupus.
MethodsToll‐like receptor 7 (TLR‐7) ligand–driven lupus was induced by injection of pristane into C57BL/6...
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