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The aim of this study was elucidate the inhibitory role of growth differentiation factor 15 (GDF15) in liver fibrosis and its possible activation mechanism in hepatic stellate cells (HSCs) of mice. We generated a GDF15‐neutralizing antibody that can inhibit TGF‐β1–induced activation of the TGF‐β/Smad2/3 pathway in LX‐2 cells. All the mice in this study were induced by carbon tetrachloride and thioacetamide...
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