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Prostate cancer (PCa) is the most common malignant tumor in males, which frequently develops into castration‐resistant prostate cancer (CRPC) with limited therapies. Gambogenic acid (GNA), a flavonoids compound isolated from Gamboge, exhibits anti‐tumor capacity in various cancers. Our results showed that GNA revealed not only antiproliferative and pro‐apoptotic activities but also the induction of...
Tributyltin (TBT), one of the environmental pollutants, has been shown to impact the reproduction of animals. However, due to the lack of appropriate animal model, analysis of the affected molecular pathways in germ cells is lagging and has been particularly challenging. In the present study, we investigated the effects of tributyltin chloride (TBTCL) on the nematode Caenorhabditis elegans germline...
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