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Adapting the final sample size of a trial to the evidence accruing during the trial is a natural way to address planning uncertainty. Since the sample size is usually determined by an argument based on the power of the trial, an interim analysis raises the question of how the final sample size should be determined conditional on the accrued information. To this end, we first review and compare common...
In this paper, we derive the joint distribution of progression‐free and overall survival as a function of transition probabilities in a multistate model. No assumptions on copulae or latent event times are needed and the model is allowed to be non‐Markov. From the joint distribution, statistics of interest can then be computed. As an example, we provide closed formulas and statistical inference for...
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