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We previously obtained evidence for intrinsic aminopeptidase activity for leukotriene (LT)A 4 hydrolase, an enzyme characterized to specifically catalyse the hydrolysis of LTA 4 to LTB 4 , a chemotactic compound. From a sequence homology search between LTA 4 hydrolase and several aminopeptidases, it became clear that they share a putative active site for known aminopeptidases...
The cDNA clone encoding human leukotriene A 4 hydrolase was inserted into a vector pUC9 and expressed in Escherichia coli as a fusion protein containing the first 10 amino acid residues derived from a vector. The leukotriene A 4 hydrolase activity was recovered in the soluble fraction of the transformants. The purified enzyme showed kinetic properties similar to the native enzyme,...
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