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This study investigated the pathway underlying the antitumor activity of telomelysin, a telomerase‐dependent, replication‐selective oncolytic adenovirus, in soft tissue sarcoma cells. Treatment with telomelysin alone resulted in simultaneous induction of apoptosis and autophagy, whereas cotreatment with telomelysin and 3‐methyladenine significantly reduced cell viability and increased apoptosis and...
(Cancer Sci 2010; 101: 759–766)
Matrix metalloproteinase (MMP)‐9, the 92‐kDa type IV collagenase, contributes to tumor invasion and metastases, and strategies to down‐regulate its expression could ultimately be of clinical utility. A pyrrole‐imidazole (PI) polyamide that targets the activator protein‐1 (AP‐1)‐binding site of the MMP‐9 promoter was designed and synthesized as a gene‐silencing agent...
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