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We investigated the molecular mechanism underlying the effect of fenofibrate on expression of plasminogen activator inhibitor type-1 (PAI-1) in HepG2 cells.Luciferase reporter gene plasmids containing four sequentially truncated fragments of the PAI-1 promoter region (−804 to +17) were constructed and plasmids carrying constructs of Smad binding element (SBE)-site-directed deletions in the PAI-1 promoter...
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