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Objective: To assess the feasibility of measuring short-term effects of inhaled recombinant human deoxyribonuclease (rhDNase, Pulmozyme ( R)) on lung function, pulse oximetry and symptom scores in infants and toddlers with stable cystic fibrosis. Design: open-label randomized placebo controlled cross-over pilot study. Patients and methods: We treated nine CF patients (0.7-1.9 years) with nebulised...
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