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Controlled ovarian hyperstimulation (COH) results in supraphysiologic levels of maternal serum estradiol (E 2 ) during the luteal phase, thus promoting oocyte production at unknown risk to the subsequently developing embryo. Human embryonic stem cells (hESCs) have been identified as a model system to assess the impact of COH on early embryonic development, specifically 17β-estradiol mediated...
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