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Cyclodextrins (CDs) have utility for solubilizing and stabilizing drugs. Recently CDs have been foused as therapeutics for neurodegenerative diseases. However, some CDs are toxic when administered parenterally. In this study, we investigated the effects of MβCD, a methylated form of β-CD, on endothelial cells using ECV 304 cells, a human endothelial cell line. Pretreatment of MβCD increased NO production...
The aim of the present studywas to examine the question of whether the atrial natriuretic peptide (ANP) system is altered by endothelial nitric-oxide synthase (eNOS).Male eNOS-deficient mice (eNOS−/−) and wild type control mice (eNOS+/+, C57B1/6J) were used. Blood pressure was measured in anesthetized mice by tail cuff plethysmography and renal function was measured. Expression of ANP, natriuretic...
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