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In the post-genomic era, discovering relationships between genes and further constructing gene regulatory networks (GRNs) is an important problem in system biology. In case the GRNs model for a cell is known, we can simulate the gene expression to predict future states of the cell and discover new drugs based on the relationships in the GRNs. In this paper, our aim is to construct a better gene regulatory...
Alternative splicing is the main mechanism expanding proteome diversity. Cryptic exon is an important alternative splicing form that is different from skipped exon in statistical characters. We introduce a process to identify the human cryptic exons in candidate ones. This method contains two steps performed by two classifiers based on the support vector machine (SVM). The first classifier distinguishes...
With the imminent completion of the Human Genome Project and the fast increase of many complete genomes of prokaryotes and eukaryotes, the task of organizing and understanding the generated sequence and structural data becomes more and more pressing and demands better and efficient analysis algorithms. Computational gene identification is an issue of obvious importance as a tool of identifying biologically...
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