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Polymer-based, covalently linked drug-delivery systems have been shown to improve the therapeutic index of effective but toxic anticancer agents, such as cisplatin, by exploiting the peculiar features of tumour blood and lymphatic circulation. In the present study, positively charged poly(methylmetacrylate) core–shell nanospheres (ZN2) were used as pharmacophores for anionic platinum-containing moieties...
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