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The contribution of melanocortin‐1 receptor (MC1R) gene variants to the development of early‐onset melanoma is unknown. Using an Australian population‐based, case‐control‐family study, we sequenced MC1R for 565 cases with invasive cutaneous melanoma diagnosed between ages 18 and 39 years, 409 unrelated controls and 518 sibling controls. Variants were classified a priori into “R” variants (D84E, R142H,...
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