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The pink-eyed dilution phenotype in mice arises from mutations in thepgene; in humans, analogous mutations in thePgene result in oculocutaneous albinism type 2. Although the molecular mechanisms which underlie this phenotype remain obscure, it has been postulated that mutations inpresult in defective tyrosine transport into murine melanosomes, resulting in hypopigmentation and diminished coat color...
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