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Background
Boys with acute lymphoblastic leukemia (ALL) have historically experienced inferior survival compared to girls. This study determined whether sex‐based disparities persist with contemporary therapy and whether patterns of treatment failure vary by sex.
Methods
Patients 1 to 30.99 years old were enrolled on frontline Children’s Oncology Group trials between 2004 and 2014. Boys received...
BACKGROUND
Children, adolescents, and young adults with very high‐risk (VHR) B acute lymphoblastic leukemia (B‐ALL) have poor outcomes, and novel therapies are needed for this subgroup. The AALL1131 study evaluated postinduction therapy using cyclophosphamide (CPM), etoposide (ETOP), and clofarabine (CLOF) for patients with VHR B‐ALL.
METHODS
Patients who were 1 to 30 years old and had VHR B‐ALL...
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