Search results for: Ian F. Pollack

Items from 1 to 20 out of 78 results

article

Longitudinal CSF Iron Pathway Proteins in Posthemorrhagic Hydrocephalus: Associations with Ventricle Size and Neurodevelopmental Outcomes

Jennifer M. Strahle, Kelly B. Mahaney, Diego M. Morales, Chandana Buddhala, more

Annals of Neurology > 90 > 2 > 217 - 226

Objective Iron has been implicated in the pathogenesis of brain injury and hydrocephalus after preterm germinal matrix hemorrhage‐intraventricular hemorrhage, however, it is unknown how external or endogenous intraventricular clearance of iron pathway proteins affect the outcome in this group. Methods This prospective multicenter cohort included patients with posthemorrhagic hydrocephalus (PHH)...

article

Quantifying radiation therapy response using apparent diffusion coefficient (ADC) parametric mapping of pediatric diffuse intrinsic pontine glioma: a report from the pediatric brain tumor consortium

Rafael Ceschin, Mehmet Kocak, Sridhar Vajapeyam, Ian F. Pollack, more

Journal of Neuro-Oncology > 2019 > 143 > 1 > 79-86

Background and purpose Baseline diffusion or apparent diffusion coefficient (ADC) characteristics have been shown to predict outcome related to DIPG, but the predictive value of post-radiation ADC is less well understood. ADC parametric mapping (FDM) was used to measure radiation-related changes in ADC and compared these metrics to baseline ADC in predicting progression-free survival and overall survival...

article

Mitochondrial dysfunction RAD51, and Ku80 proteolysis promote apoptotic effects of Dinaciclib in Bcl‐xL silenced cells

Daniel R. Premkumar, Esther P. Jane, Swetha Thambireddy, Philip A. Sutera, more

Molecular Carcinogenesis > 57 > 4 > 469 - 482

In the present study, we investigated the effect of CDK inhibitors (ribociclib, palbociclib, seliciclib, AZD5438, and dinaciclib) on malignant human glioma cells for cell viability, apoptosis, oxidative stress, and mitochondrial function using various assays. None of the CDK inhibitors induced cell death at a clinically relevant concentration. However, low nanomolar concentrations of dinaciclib showed...

article

Regulatory T cell subsets in patients with medulloblastoma at diagnosis and during standard irradiation and chemotherapy (PBTC N-11)

Sridharan Gururangan, Elizabeth Reap, Robert Schmittling, Mehmet Kocak, more

Cancer Immunology, Immunotherapy > 2017 > 66 > 12 > 1589-1595

Background We evaluated circulating levels of immunosuppressive regulatory T cells (T_regs) and other lymphocyte subsets in patients with newly diagnosed medulloblastoma (MBL) undergoing surgery compared to a control cohort of patients undergo craniectomy for correction of Chiari malformation (CM) and further determined the impact of standard irradiation and chemotherapy on this cell population. ...

article

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Florence M.G. Cavalli, Marc Remke, Ladislav Rampasek, John Peacock, more

Cancer Cell > 2017 > 31 > 6 > 737-754.e6

While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number...

article

Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl‐xL silenced glioma cell lines

Esther P. Jane, Daniel R. Premkumar, Philip A. Sutera, Jonathon M. Cavaleri, more

Molecular Carcinogenesis > 56 > 4 > 1251 - 1265

Because the anti‐apoptotic protein Bcl‐xL is overexpressed in glioma, one might expect that inhibiting or silencing this gene would promote tumor cell killing. However, our studies have shown that this approach has limited independent activity, but may tip the balance in favor of apoptosis induction in response to other therapeutic interventions. To address this issue, we performed a pharmacological...

article

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Casey Ager, Matthew Reilley, Courtney Nicholas, Todd Bartkowiak, more

Journal for ImmunoTherapy of Cancer > 2016 > 4 > 1 > 107-221

chapter

Optic Gliomas

Ian F. Pollack, Regina I. Jakacki

Oncology of CNS Tumors > Pediatric Neuro-Oncology > 395-404

The term “optic glioma” encompasses a diverse group of tumors that can arise anywhere along the visual pathway from the globe to the optic radiations. A particularly challenging subgroup of these tumors involves the hypothalamus in conjunction with the optic chiasm. Because complete resection of such lesions is not feasible without excessive morbidity, a variety of adjuvant management options have...

article

Nonrandomized comparison of neurofibromatosis type 1 and non–neurofibromatosis type 1 children who received carboplatin and vincristine for progressive low‐grade glioma: A report from the Children's Oncology Group

Joann L. Ater, Caihong Xia, Claire M. Mazewski, Timothy N. Booth, more

Cancer > 122 > 12 > 1928 - 1936

BACKGROUNDTo evaluate tumor responses, event‐free survival (EFS), overall survival (OS), and toxicity of chemotherapy, children with neurofibromatosis type 1 (NF1) and progressive low‐grade glioma were enrolled into the Children's Oncology Group (COG) A9952 protocol and treated with carboplatin and vincristine (CV). METHODSNon‐NF1 patients were randomized to CV or thioguanine, procarbazine, 1‐(2‐chloroethyl)‐3‐cyclohexyl‐1‐nitrosourea,...

article

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

Eric M Thompson, Thomas Hielscher, Eric Bouffet, Marc Remke, more

The Lancet Oncology > 2016 > 17 > 4 > 484-495

Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed...

chapter

Epidermal Growth Factor Receptor Inhibition as a Therapeutic Strategy for Glioblastoma Multiforme

Nikhil G. Thaker, Ian F. Pollack

Tumors of the Central Nervous System > Tumors of the Central Nervous System, Volume 1 > Therapy > 321-336

Because of the poor responsiveness of glioblastoma multiforme to conventional therapies, there is a need to identify novel therapeutic strategies to improve patient survival. Growth factors, growth factor receptors, and their signal transduction pathways are normally implicated in cell survival and proliferation, and in tumor cells, aberrant regulation of these pathways is common and may effect tumorigenesis...

chapter

Molecularly Targeted Therapies for Astrocytomas

Ian F. Pollack

Molecularly Targeted Therapy for Childhood Cancer > Solid Tumors > 231-265

Astrocytomas constitute the largest group of central nervous system (CNS) neoplasms during childhood, and incorporate tumors with diverse histological features and biological characteristics (Pollack 1994). Whereas patients with superficial low-grade gliomas are often cured with surgery alone, patients with deep-seated or malignant gliomas continue to have a suboptimal prognosis, despite recent improvements...

article

Shotgun pellet embolization to the posterior cerebral artery

Michael M. McDowell, Xiao Zhu, Steven Johnson, Christopher Deibert, more

Child's Nervous System > 2016 > 32 > 7 > 1317-1320

Introduction Projectile embolization to the cerebral vasculature and is almost exclusively seen in the anterior circulation due to the greater diameter and flow of the internal carotid arteries. In children, this phenomenon is ever rarer. Methods We present a case of a 9-year-old boy who suffered from a shotgun blast to the thorax and abdomen. He was subsequently found to have a pellet that had...

article

A molecular biology and phase II study of imetelstat (GRN163L) in children with recurrent or refractory central nervous system malignancies: a pediatric brain tumor consortium study

Ralph Salloum, Trent R. Hummel, Shiva Senthil Kumar, Kathleen Dorris, more

Journal of Neuro-Oncology > 2016 > 129 > 3 > 443-451

Telomerase activation is critical in many cancers including central nervous system (CNS) tumors. Imetelstat is an oligonucleotide that binds to the template region of the RNA component of telomerase, inhibiting its enzymatic activity. We conducted an investigator-sponsored molecular biology (MB) and phase II study to estimate inhibition of tumor telomerase activity and sustained responses by imetelstat...

article

Immunotherapy response assessment in neuro-oncology: a report of the RANO working group

Hideho Okada, Michael Weller, Raymond Huang, Gaetano Finocchiaro, more

The Lancet Oncology > 2015 > 16 > 15 > e534-e542

Immunotherapy is a promising area of therapy in patients with neuro-oncological malignancies. However, early-phase studies show unique challenges associated with the assessment of radiological changes in response to immunotherapy reflecting delayed responses or therapy-induced inflammation. Clinical benefit, including long-term survival and tumour regression, can still occur after initial disease...

article

Pilot Study of Intensive Chemotherapy With Peripheral Hematopoietic Cell Support for Children Less Than 3 Years of Age With Malignant Brain Tumors, the CCG-99703 Phase I/II Study. A Report From the Children's Oncology Group

Bruce H. Cohen, J. Russell Geyer, Douglas C. Miller, John G. Curran, more

Pediatric Neurology > 2015 > 53 > 1 > 31-46

The primary goals of the Children's Cancer Group 99703 study were to assess the feasibility and tolerability of—as well as the response rate to—a novel dose-intensive chemotherapy regimen.Between March 1998 and October 2004, 92 eligible patients were enrolled. Following biopsy/resection, patients received three identical cycles of Induction chemotherapy (vincristine, cyclophosphamide, etoposide, and...

article

Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors treated with carboplatin during radiotherapy: A report from the Children's Oncology Group

Regina I. Jakacki, Peter C. Burger, Mehmet Kocak, James M. Boyett, more

Pediatric Blood & Cancer > 62 > 5 > 776 - 783

BackgroundSupratentorial PNETs (sPNET) are uncommon embryonal malignancies of the central nervous system whose prognosis has historically been poor. We evaluated the outcome and prognostic factors of children with sPNET treated prospectively on a Children's Oncology Group trial. ProcedureFollowing surgery, patients received craniospinal radiotherapy with concurrent carboplatin followed by six months...

article

A rare cause of reversible ophthalmoplegia: tension pneumocephalus with brainstem compression

Samuel A. Lindner, Ian F. Pollack, Hoda Abdel-Hamid, Giulio Zuccoli

Neuroradiology > 2015 > 57 > 7 > 761-762

article

Impact of tumor location and pathological discordance on survival of children with midline high-grade gliomas treated on Children’s Cancer Group high-grade glioma study CCG-945

David D. Eisenstat, Ian F. Pollack, Alain Demers, Mark V. Sapp, more

Journal of Neuro-Oncology > 2015 > 121 > 3 > 573-581

Children with high-grade glioma (HGG) have a poor prognosis compared to those with low-grade glioma (LGG). Adjuvant chemotherapy may be beneficial, but its optimal use remains undetermined. Histology and extent of resection are important prognostic factors. We tested the hypothesis that patients with midline HGG treated on Children’s Cancer Group Study (CCG) CCG-945 have a worse prognosis compared...

article

Bevacizumab for symptomatic radiation‐induced tumor enlargement in pediatric low grade gliomas

Kimberly A. Foster, William J. Ares, Ian F. Pollack, Regina I. Jakacki

Pediatric Blood & Cancer > 62 > 2 > 240 - 245

Background Radiation therapy (RT)‐induced effects in children treated for low grade glioma (LGG) can result in worsening of neurologic symptoms and clinical and radiographic deterioration. Treatment for radiation‐induced tumor enlargement is based on symptom control and usually involves steroids. Procedure We conducted a retrospective review of children with LGG treated with RT who developed symptomatic...

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Search results for: Ian F. Pollack

Longitudinal CSF Iron Pathway Proteins in Posthemorrhagic Hydrocephalus: Associations with Ventricle Size and Neurodevelopmental Outcomes

Quantifying radiation therapy response using apparent diffusion coefficient (ADC) parametric mapping of pediatric diffuse intrinsic pontine glioma: a report from the pediatric brain tumor consortium

Mitochondrial dysfunction RAD51, and Ku80 proteolysis promote apoptotic effects of Dinaciclib in Bcl‐xL silenced cells

Regulatory T cell subsets in patients with medulloblastoma at diagnosis and during standard irradiation and chemotherapy (PBTC N-11)

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl‐xL silenced glioma cell lines

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Optic Gliomas

Nonrandomized comparison of neurofibromatosis type 1 and non–neurofibromatosis type 1 children who received carboplatin and vincristine for progressive low‐grade glioma: A report from the Children's Oncology Group

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

Epidermal Growth Factor Receptor Inhibition as a Therapeutic Strategy for Glioblastoma Multiforme

Molecularly Targeted Therapies for Astrocytomas

Shotgun pellet embolization to the posterior cerebral artery

A molecular biology and phase II study of imetelstat (GRN163L) in children with recurrent or refractory central nervous system malignancies: a pediatric brain tumor consortium study

Immunotherapy response assessment in neuro-oncology: a report of the RANO working group

Pilot Study of Intensive Chemotherapy With Peripheral Hematopoietic Cell Support for Children Less Than 3 Years of Age With Malignant Brain Tumors, the CCG-99703 Phase I/II Study. A Report From the Children's Oncology Group

Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors treated with carboplatin during radiotherapy: A report from the Children's Oncology Group

A rare cause of reversible ophthalmoplegia: tension pneumocephalus with brainstem compression

Impact of tumor location and pathological discordance on survival of children with midline high-grade gliomas treated on Children’s Cancer Group high-grade glioma study CCG-945

Bevacizumab for symptomatic radiation‐induced tumor enlargement in pediatric low grade gliomas

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