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A set of 15 cyclic‐hexaalanine and 10 cyclic‐pentaalanine peptides containing one or two backbone N‐aryl amide bonds were synthesized by following a combination of solution‐phase and solid‐phase peptide synthesis. NMR‐based conformation studies of these N‐aryl cyclic‐hexaalanine peptides revealed five distinct template conformations with an antiparallel β‐sheet structure; for N‐aryl cyclic‐pentaalanine...
N‐aryl amide bonds for peptide conformation: In the universe of peptides, the N‐aryl amide bond, with its large steric and electronic effects and ability to restrain amide bond rotation, is represented as a new star. By employing N‐arylation as a backbone amide modification strategy in peptides, we could unravel the different worlds of distinct and predominantly homogeneous conformations in cyclic...