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Abstract
The lower oesophageal sphincter (LES) generates tone and prevents reflux of gastric contents. LES smooth muscle cells (SMCs) are relatively depolarised, facilitating activation of Cav1.2 channels to sustain contractile tone. We hypothesised that intramuscular interstitial cells of Cajal (ICC‐IM), through activation of Ca2+‐activated Cl− channels (ANO1), set membrane potentials of SMCs favourable...
Non‐technical summary What is known about gastric electrophysiology and used in motility clinics throughout the world is mostly deduced from animal studies and extracellular recordings from human patients. Extracellular recording from gastrointestinal muscles, however, is prone to extensive motion artifact, and it is not clear that animal models can be translated directly to human physiology. Therefore,...
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