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Lipoxins (LXs) are potent endogenous counter-regulatory lipid mediators that dampen acute inflammation and promote its resolution. Here, we present our investigation of a new class of thermally and metabolically stable benzo-LXA 4 analogs that are potently anti-inflammatory and easier to synthesize. Replacement of the tetraene unit of native LXA 4 with a benzo-fused ring system not...
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