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Introduction: We have shown that bile salts have a beneficial effect on the intestinal mucosa by stimulating epithelial growth and repair through NF-kappaB activation and c-myc expression. We hypothesized that bile salts would also effect enterocyte susceptibility to apoptosis. To determine this, we studied the effect of the bile salt taurodeoxycholate (TDCA) on cultured rat enterocyte (IEC-6 cells)...
Introduction: Intestinal epithelial cells reseal mucosal wounds through migration. This process of mucosal restitution is vital for many intestinal functions. Recent evidence implicates a role for Substance P (SP), a common neurotransmitter in the neurons of the intestinal mucosa, in the maintenance of gastrointestinal mucosal integrity. We have previously demonstrated that SP increases migration...
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