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The effects of systemically administered interleukin-1β (1.0 μg), interleukin-6 (1.0 μg) and interleukin-2 (1.0 μg) on in vivo variations of monoamines were assessed in the nucleus accumbens. Administration of interleukin-1β did not affect extracellular accumbal dopamine, provoked a modest rise of homovanillic acid, and prevented the decline of dihydroxyphenylacetic acid ordinarily seen in saline...
The aims of this study were to examine the plasma availability of tryptophan, the precursor of 5-hydroxytryptamine (5-HT), and serum cytokines, such as interleukin-6 (IL-6) and IL-8, in normal elderly volunteers and in patients with Alzheimer’s disease (DAT). Elderly normal volunteers (mean age=78.3±5.7 years) had a significantly lower tryptophan/competing amino acids (valine+leucine+isoleucine+phenylalanine+tyrosine)...
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