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Visualizing dynamic graphs are challenging due to the difficulty to preserving a coherent mental map of the changing graphs. In this paper, we propose a novel layout algorithm which is capable of maintaining the overall structure of a sequence graphs. Through Laplacian constrained distance embedding, our method works online and maintains the aesthetic of individual graphs and the shape similarity...
Understanding the regulating mechanism of tumor invasion is of crucial importance for both fundamental cancer research and clinical applications. Previous in vivo experiments have shown that invasive cancer cells dissociate from the primary tumor and invade into the stroma, forming an irregular invasive morphology. Although cell movements involved in tumor invasion are ultimately driven by mechanical...
Space-filling visualization techniques have proved their capability in visualizing large hierarchical structured data. However, most existing techniques restrict their partitioning process in vertical and horizontal direction only, which cause problem with identifying hierarchical structures. According to Gestalt research, limiting tree map visualisation to rectangles blocks the utilisation of human...
Regulation of cell growth and proliferation has a fundamental role in tissue development, organogenesis, and disease progression. Conserved distribution of the number of sides of cells with a mean value of six was found in a variety of proliferating epithelia. Previous studies have shown that clones of proliferating cells bounded by quiescent cells have fewer sides than normal epithelia. However,...
Highlighting was the basic viewing control mechanism in computer graphics and visualization to guide users' attention in reading diagrams, images, graphs and digital texts. As the rapid growth of theory and practice in information visualization, highlighting has extended its role that acts as not only a viewing control, but also an interaction control and a graphic recommendation mechanism in knowledge...
Regulation of proliferation is required for normal development of tissues and prevention of cancer formation. Continuous control of proliferation leads to regular shaped cells forming characteristic tissue patterns. Epithelial tissues serve as a model system for studying tissue morphogenesis. Several groups have studied epithelial morphogenesis using topological or geometric models, with various assumptions...
Proteins contain thousands or more atoms and have complex shapes. We discuss here the computation of protein packing defects, in the form of voids and pockets, from experimentally resolved protein structures, and the nature of their distribution and scaling behavior, as well as their origin. We further discuss how evolutionary selection pressure due to biological function unaltered by selection pressure...
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