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Estrogen Receptor‐β (ER‐β), a tumor‐suppressor in prostate cancer, is epigenetically repressed by hypermethylation of its promoter. DNA‐methyltransferases (DNMTs), which catalyze the transfer of methyl‐groups to CpG islands of gene promoters, are overactive in cancers and can be inhibited by DNMT‐inhibitors to re‐express the tumor suppressors. The FDA‐approved nucleoside DNMT‐inhibitors like 5‐Azacytidine...
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