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Argyrophilic and tau‐positive abnormal structures in astrocytes are frequent in aged brains, with a new nomenclature of aging‐related tau astrogliopathy (ARTAG) proposed. The two major cytomorphologies of ARTAG are thorn‐shaped astrocytes (TSA) and granular or fuzzy tau immunoreactivity in processes of astrocytes (GFA). We selected 28 cases in which many AT8‐identified astrocytic tauopathies were...
Here, we report a case of Cockayne syndrome (CS) in a Japanese man who displayed a unique pathology of phosphorylated trans‐activation response (TAR) DNA‐binding protein 43 (pTDP‐43) with abundant Rosenthal fibers. Many round pTDP‐43‐positive structures were detected throughout the CNS; however, most of them were located in two regions that also exhibited neuronal depletion: the cerebellar cortex...
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