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Diffusion in the extracellular and intracellular spaces (ECS and ICS, respectively) was evaluated in excised spinal cords, before and after cell swelling induced by glutamate, by high b-value q-space diffusion MR of specific markers and water. The signal decays of deuterated tetramethylammonium (TMA-d 12 ) chloride, an exogenous marker of the ECS, and N-acetyl aspartate (NAA), an endogenous...
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