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Large‐scale genome‐wide analyses scans on massive numbers of various cases and controls are archived in the genetic databases that are publically available, for example, the Database of Genotypes and Phenotypes (https://www.ncbi.nlm.nih.gov/gap/). These databases offer unprecscendented opportunity to study the genetic effects. Yet, the set of nongenetic variables in these databases is often brief...
Genetic studies provide valuable information to assess if the effect of genetic variants varies by the nongenetic “environmental” variables, what is traditionally defined to be gene–environment interaction (GxE). A common complication is that multiple disease states present with the same set of symptoms, and hence share the clinical diagnosis. Because (a) disease states might have distinct genetic...
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