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In normal exercising muscle, there is reduced excitability and slowed propagation velocity across the muscle membrane leading to a reduced amplitude and a prolonged duration of the compound muscle action potential. Whether this change in the muscle membrane contributes to fatigue in healthy individuals is still somewhat controversial. In multiple sclerosis where fatigue is a major symptom, exercise...
Both metabolic factors and impairment of activation appear to play a role in the development of human muscle fatigue. By measuringforce EMG and metabolites using 31P magnetic resonance spectroscopy during fatiguing exercise in recovery it is possible to estimate the contribution of different factors which produce fatigue. In healthy motivated persons central fatigue plays a minor role compared with...
In normal exercising muscle, there is reduced excitability and slowed propagation velocity across the muscle membrane leading to a reduced amplitude and a prolonged duration of the compound muscle action potential. Whether this change in the muscle membrane contributes to fatigue in healthy individuals is still somewhat controversial. In multiple sclerosis where fatigue is a major symptom, exercise...
Both metabolic factors and impairment of activation appear to play a role in the development of human muscle fatigue. By measuringforce EMG and metabolites using 31P magnetic resonance spectroscopy during fatiguing exercise in recovery it is possible to estimate the contribution of different factors which produce fatigue. In healthy motivated persons central fatigue plays a minor role compared with...
Calcium channel blocking drugs antagonize excitatory amino acid receptor activation, decrease calcium entry into damaged neurons, and might help to slow or reverse amyotrophic lateral sclerosis (ALS). We enrolled 87 patients with ALS in a randomized, placebo-controlled, prospective, double-blind crossover study of nimodipine therapy. Monthly measures of isometric muscle strength and respiratory function...
In motivated and healthy young subjects, central fatigue is usually not significant, however, in many patients with neuromuscular diseases, central fatigue is an important component of the fatigue process. To assess central fatigue quantitatively, we utilize the measurement of added force in response to a brief tetanic train of stimuli superimposed upon a maximum voluntary contraction. In addition,...
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