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Bioluminescence Tomography (BLT) reconstruction is a highly ill-posed inverse problem. In this research, we formulate it as a quadratically constrained least squares problem and present a trust region method for solving this problem. Simulations based on a heterogeneous phantom demonstrate that the trust region method has the capability to effectively handle the ill-posedness of BLT. The experiments...
Bioluminescence tomography is a new modality of optical molecular imaging for localizing and quantifying bioluminescence source in a small living animal. The reconstruction of internal bioluminescent source is still a difficult problem. In this paper, a trial and error approach based on Monte Carlo method is developed for localizing the bioluminescent source. The iteration number of the trial and...
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