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Tetrahedral framework nucleic acids (tFNAs) have attracted extensive attention as drug nanocarriers because of their excellent cellular uptake. However, for oligonucleotide cargos, tFNA mainly acts as a static delivery platform generated via sticky‐ended ligation. Here, inspired by the original stable space inside the tetrahedral scaffold, a dynamic lysosome‐activated tFNA nanobox is fabricated for...
DNA Nanotechnology
Tetrahedral framework nucleic acids have attracted extensive attention as a static drug nanocarrier. In article number 2201731, Xiaxiao Cai and co‐workers report a dynamic lysosome‐activated tetrahedral nanobox for completely encapsulating short interfering RNA. The closed tetrahedral structure endows cargo RNA with active release. This work offers a dynamic pH‐sensitive confinement...
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