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To evaluate normobaric hypoxia-induced brain damage and discuss the mechanism in wistar rat brain injury, the water content of brain , brain infarction area ratio , the level of lactic acid and Na+-K+-ATPase activity were detected. The expression of HIF-lalpha was confirmed using immunohistochemistry. Histopathological changes of brain in rat model due to hypoxia were investigated using hematoxylin...
To study the time course of oxidative damage and the molecular and cellular mechanisms underlying hypoxia-induced brain damage, some stress responses to hypoxia in rat brain, such as lactic acid(LA) and malondialdehyde (MDA) expression, superoxide dismutase (SOD) and Na+-K+-ATPase activity etc, were analysed. The role of those factors in oxidative stress was discussed too. Results showed that the...
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