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The secreted glycoprotein Dickkopf-1 (Dkk1), an antagonist of the Wnt/β-catenin pathway, has been implicated in many neurodegenerative diseases. However, it is unknown whether Dkk1 is involved in the pathogenesis of Parkinson's disease (PD). In this study, we discovered that Dkk1 was induced in MPP + -treated PC12 cells and the increase of Dkk1 preceded PC12 cell loss. RhDkk1 aggravated the...
Although the etiology of Alzheimer's disease (AD) is not fully understood, multiple lines of evidence suggests the importance of amyloid-β (Aβ) in the initiation/progression of the disease. In this study, we investigated protective effects of erythropoietin (EPO) on Aβ 25–35 -induced cell death in cultured rat pheochromocytoma cells (PC12 cells). EPO (2U/ml) in combination with Aβ 25–35...
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