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Candida albicans is the most common fungal pathogen of mucosal infections and invasive diseases in immuno‐compromised humans. The abilities of yeast–hyphal growth and white–opaque switching affect C. albicans physiology and virulence. Here, we showed that C. albicans Aft2 regulator was required for embedded filamentous growth and opaque cell‐type formation. Under low‐temperature matrix embedded conditions,...
Iron is an essential nutrient required for the growth and metabolism in Candida albicans. Here, we for the first time identified Mrs4 as a new member of mitochondrial carrier family in C. albicans. Our experiments revealed that C. albicans Mrs4 (CaMrs4) is localized to the mitochondria and required for mitochondrial morphology. We found that CaMrs4 is required for cell growth, and the mrs4△/△ mutant...
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