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Chronic hepatitis B (CHB) patients with higher hepatitis B virus (HBV) load (higher viral load [HVL], HBV DNA ≥1 × 107 copies/mL) require antiviral therapy, but data for evaluating the long‐term outcome of this therapy with antiviral agents remain limited. We comparatively evaluated the efficacy and the safety of nucleoside analogues in 179 noncirrhotic CHB patients with HVL over 5 years. The HBeAg‐positive...
Summary. T helper (Th) 17 cells have been demonstrated to participate in the pathogenesis of HBV‐associated liver damage. However, little is known regarding the immunopathogenic role of liver fibrosis in patients with HBV‐associated liver cirrhosis. The aims of this study were to evaluate whether Th17 cells are related to disease progression in patients and to explore the possible mechanisms. The...
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