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Summary CD46 is not only identified as a complement regulatory protein which protects host cells from complement attack, but also a new co-stimulatory molecule for human T cells. CD3/CD46 co-stimulation can induce a T-regulatory 1 cell (Tr1)-specific cytokine phenotype in human CD4+ T cells. However, the role of CD46 as a co-stimulatory molecule in the modulation of the acquired immunity, such as...
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