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In article number 1903254, Jia Guo, Yu Chen, Huixiong Xu, and co‐workers fabricate ultrasmall dual‐targeting iridium nanocrystals modified with tumor cell‐targeting RGD peptides and nucleus‐targeting TAT proteins for effective tumor localization and nucleus targeting, inducing prominent sensitized tumor radiotherapy.
Prominent tumor‐cell nucleus targeting of radiosensitizer substantially affects the therapeutic consequence of advanced tumor radiotherapy via lethal nucleus DNA damage. Herein, ultrasmall iridium nanocrystals (Ir NCs, <5 nm) are constructed for efficient tumor‐specific photonic hyperthermia‐synergized radiotherapy. To endow the NCs with qualified cell nucleus‐targeting performance, polyethylene...
Background The adjuvant treatment for patients with isolated stromal invasion after radical hysterectomy and pelvic lymph node dissection (PLND) in FIGO stage IB1 and IIA1 cervical carcinoma has not been established. This study assessed the survival outcomes and recurrent patterns in this particular group of patients treated with chemotherapy or radiation-based adjuvant therapy. Methods The records...
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