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Lipopolysaccharide (LPS) can exacerbate asthma; however, the mechanisms are not fully understood. This study investigated the effect of LPS on antigen‐stimulated mast cell degranulation and the underlying mechanisms. We found that LPS enhanced degranulation in RBL‐2H3 cells and mouse peritoneal mast cells upon FcɛRI activation, in a dose‐ and time‐dependent manner. Parallel to the alteration of degranulation,...
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