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Objective
Bone marrow–derived mesenchymal stem cells (BM‐MSCs) create a special microenvironment for hematopoiesis and immunity and display robust immunomodulatory properties that are impaired in systemic lupus erythematosus (SLE). This study was undertaken to identify the mechanisms of defects in human SLE BM‐MSCs.
Methods
Patients fulfilling SLE classification criteria and healthy controls (n...
ObjectiveTo investigate the biologic significance of Smad3 in the progression of osteoarthritis (OA), the crosstalk between Smad3 and activating transcription factor 2 (ATF‐2) in the transforming growth factor β (TGFβ) signaling pathway, and the effects of ATF‐2 overexpression and p38 activation in chondrocyte differentiation.
MethodsJoint disease in Smad3‐knockout (Smad3−/−) mice was examined by...
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