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Single‐atom nanozymes (SAzymes) are emerging natural enzyme mimics and have attracted much attention in the biomedical field. SAzymes with Metal─Nx sites designed on carbon matrixes are currently the mainstream in research. It is of great significance to further expand the types of SAzymes to enrich the nanozyme library. Single‐atom alloys (SAAs) are a material in which single‐atom metal sites are...
The free radical generation efficiency of nanozymes in cancer therapy is crucial, but current methods fall short. Alloy nanoparticles (ANs) hold promise for improving catalytic performance due to their inherent electronic effect, but there are limited ways to modulate this effect. Here, a self‐driven electric field (E) system utilizing triboelectric nanogenerator (TENG) and AuPd ANs with glucose oxidase...
Fluorescence‐based PCR and other amplification methods have been used for SARS‐CoV‐2 diagnostics, however, it requires costly fluorescence detectors and probes limiting deploying large‐scale screening. Here, a cut‐price colorimetric method for SARS‐CoV‐2 RNA detection by iron manganese silicate nanozyme (IMSN) is established. IMSN catalyzes the oxidation of chromogenic substrates by its peroxidase...
Cancer stem cells (CSCs), a type of cell with self‐renewal, unlimited proliferation, and insensitivity to common physical and chemical factors, are the key to cancer metastasis, recurrence, and chemo‐resistance. Available CSCs inhibition strategies are mainly based on small molecule drugs, yet are limited by their off‐target toxicity. The link between CSCs and non‐CSCs interconversion is difficult...
Cancer diagnosis and therapeutics (theranostics) based on the tumor microenvironment (TME) and biomarkers has been an emerging approach for precision medicine. DNA nanotechnology dynamically controls the self‐assembly of DNA molecules at the nanometer scale to construct intelligent DNA chemical reaction systems. The DNA logic circuit is a particularly emerging approach for computing within the DNA...