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Human cytomegalovirus (HCMV) attenuated strains, Towne, and AD169, differ from prototypic pathogenic strains, such as Toledo, in that they are missing a ∼15‐kb segment in the UL/b′ region. In contrast to the attenuated strains, Toledo can replicate in human tissue implants in SCID (SCID‐hu) mice. Thus, this model provides a unique in vivo system to study the mechanism of viral pathogenesis. Twenty‐two...
17-hydroxylase deficiency (17OHD) has long been regarded as a rare form of congenital adrenal hyperplasia, inherited in an autosomal recessive pattern. Fifteen patients with 17OHD were described from clinical manifestations and hormone profile. Then, CYP17A1 gene was amplified and sequenced in a new patient. Heterozygous mutations c. 431_433del, p.K144del/c. 985_987delinsAA, p.Y329 fs were identified...
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